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| Nomenclature |
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Symbol:
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Mertktm1Grl
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Name:
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c-mer proto-oncogene tyrosine kinase;
targeted mutation 1, Greg Lemke
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MGI ID: |
MGI:2387765 |
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Synonyms: |
Mer-, Mertk- |
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Gene:
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Mertk
Location:
Chr2:128698956-128802894 bp, + strand
Genetic Position: Chr2,
62.63 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:54681
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 18 of the gene, which encodes part of the kinase domain known to be essential for tyrosine kinase function. An RNase protection assay demonstrated that a mutant transcript was expressed that lacked the deleted sequences. (J:54681)
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:54681
Lu Q et al.,
"Tyro-3 family receptors are essential regulators of mammalian spermatogenesis."
Nature 1999 Apr 22;398(6729):723-8
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All: |
19 reference(s)
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Analysis Tools
