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| Nomenclature |
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Symbol:
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Igh-7tm1Led
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Name:
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immunoglobulin heavy chain 7 (heavy chain of IgE);
targeted mutation 1, Philip Leder
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MGI ID: |
MGI:2387579 |
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Synonyms: |
IgE- |
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Gene:
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Igh-7
Location:
Chr12:113264521-113277715 bp
Genetic Position: Chr12,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:19552
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1 through 4 were replaced by a neomycin selection cassette inserted via homologous recombination. Transcript was undetected by Northern blot analysis of splenocytes obtained from homozygous mutant mice and stimulated with interleukin-4 and LPS. ELISA confirmed the absence of IgE. (J:19552)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Igh-7 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:19552
Oettgen HC et al.,
"Active anaphylaxis in IgE-deficient mice."
Nature 1994 Aug 4;370(6488):367-70
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All: |
14 reference(s)
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Analysis Tools
