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| Nomenclature |
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Symbol:
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Rps6ka3tm1Ljg
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Name:
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ribosomal protein S6 kinase polypeptide 3;
targeted mutation 1, Laurie J Goodyear
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MGI ID: |
MGI:2387473 |
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Synonyms: |
Rsk2-, Rsk2 KO |
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Gene:
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Rps6ka3
Location:
ChrX:159210307-159368244 bp, + strand
Genetic Position: ChrX,
73.27 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67575
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence encoding 31 residues of the amino terminal kinase domain were replaced with a neomycin selection cassette. Western blot analysis of muscle lysates confirmed the absence of normal protein in homozygous mutant mice. (J:67575)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rps6ka3 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:67575
Dufresne SD et al.,
"Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice."
Mol Cell Biol 2001 Jan;21(1):81-7
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All: |
4 reference(s)
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Analysis Tools
