|
|
| Nomenclature |
|
Symbol:
|
Htr1atm1Rhn
|
|
Name:
|
5-hydroxytryptamine (serotonin) receptor 1A;
targeted mutation 1, Rene Hen
|
|
MGI ID: |
MGI:2387407 |
|
Synonyms: |
5-HT1A |
|
Gene:
|
Htr1a
Location:
Chr13:105443693-105448133 bp, + strand
Genetic Position: Chr13,
56.92 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:51280
|
|
Parent Cell Line:
| W9.5/W95 (ES Cell) |
|
Strain of Origin:
|
129S1/Sv-Oca2+ Tyr+ Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The endogenous locus was disrupted by the insertion of a neomycin selection cassette downstream of sequence encoding the third transmembrane domain. Homozygous mutant mice were shown to lack functional receptors via autoradiography studies of brain sections. (J:51280)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Htr1a Mutation:
|
33 strains or lines available |
|
| References |
|
Original: |
J:51280
Ramboz S et al.,
"Serotonin receptor 1A knockout: an animal model of anxiety-related disorder [see comments]"
Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14476-81
|
|
All: |
24 reference(s)
|
|
Analysis Tools
