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| Nomenclature |
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Symbol:
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Stk11tm1Rdp
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Name:
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serine/threonine kinase 11;
targeted mutation 1, Ronald DePinho
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MGI ID: |
MGI:2387401 |
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Synonyms: |
Lkb- |
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Gene:
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Stk11
Location:
Chr10:80115803-80130682 bp, + strand
Genetic Position: Chr10,
39.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:78818
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Exons 3 through 6 were flanked by single loxP sites inserted into introns 2 and 6. In addition a neo cassette flanked by frt sites was inserted into intron 2, downstream of the loxP site. Mice carrying this allele were used to generate Stk11tm1.1Rdp and Stk11tm1.2Rdp. (J:78818)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:78818
Bardeesy N et al.,
"Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation."
Nature 2002 Sep 12;419(6903):162-7
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All: |
4 reference(s)
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Analysis Tools
