|
|
| Nomenclature |
|
Symbol:
|
Ptgdrtm1Sna
|
|
Name:
|
prostaglandin D receptor;
targeted mutation 1, Shuh Narumiya
|
|
MGI ID: |
MGI:2386956 |
|
Synonyms: |
DP-, DP1- |
|
Gene:
|
Ptgdr
Location:
Chr14:44851235-44859375 bp, - strand
Genetic Position: Chr14,
22.59 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:61023
|
|
Parent Cell Line:
| E14.1 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. RT-PCR analysis detected the presence of the neo insertion allele in homozygous mutant animals. Absence of protein function in homozygous mutants was confirmed by bioassay using tracheal smooth muscle samples. (J:61023)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Ptgdr Mutation:
|
1 strain or line available |
|
| References |
|
Original: |
J:61023
Matsuoka T et al.,
"Prostaglandin D2 as a mediator of allergic asthma."
Science 2000 Mar 17;287(5460):2013-7
|
|
All: |
16 reference(s)
|
|
Analysis Tools
