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| Nomenclature |
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Symbol:
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Gopctm1.1Tno
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Name:
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golgi associated PDZ and coiled-coil motif containing;
targeted mutation 1.1, Tetsuo Noda
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MGI ID: |
MGI:2386794 |
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Synonyms: |
GOPC- |
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Gene:
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Gopc
Location:
Chr10:52337024-52382124 bp, - strand
Genetic Position: Chr10,
26.54 cM, cytoband B3
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Ultrastructural analysis of spermatogenic cells from wild type and Gopctm1.1Tno/Gopctm1.1Tno mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:78599
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A floxed neo cassette was excised from Gopctm1Tno by the in vivo expression of cre recombinase. A lacZ gene remained in place of exons 2, 2b, and 3. Neither of the two protein isoforms produced by the endogenous locus were detected in homozygous mutant mice by Western blot and immunohistochemical analyses. (J:78599)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:78599
Yao R et al.,
"Lack of acrosome formation in mice lacking a Golgi protein, GOPC."
Proc Natl Acad Sci U S A 2002 Aug 20;99(17):11211-6
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All: |
6 reference(s)
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Analysis Tools
