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| Nomenclature |
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Symbol:
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Lamp2tm1Psa
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Name:
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lysosomal-associated membrane protein 2;
targeted mutation 1, Paul Saftig
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MGI ID: |
MGI:2385811 |
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Synonyms: |
LAMP-2-, Lamp2tm1Psf |
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Gene:
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Lamp2
Location:
ChrX:38401357-38456454 bp, - strand
Genetic Position: ChrX,
22.67 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64151
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into a coding exon via homologous recombination. Absence of RNA and protein expression in homozygous mutant animals was demonstrated by Northern and Western blot analysis of liver and kidney tissue. (J:64151)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lamp2 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:64151
Tanaka Y et al.,
"Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice."
Nature 2000 Aug 24;406(6798):902-6
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All: |
6 reference(s)
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Analysis Tools
