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| Nomenclature |
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Symbol:
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Tg(KLK4mHEL)6Ccg
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Name:
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transgene insertion 6, Christopher C Goodnow
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MGI ID: |
MGI:2384632 |
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Synonyms: |
KLK3, KLK-4, mHEL, mHEL-KK |
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Transgene:
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Tg(KLK4mHEL)6Ccg
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to the ubiquitously-active mouse H2-Kb promoter and transmembrane sequence (which included the extracellular spacer sequence, transmembrane segment, and cytoplasmic tail). Fluorescence activated cell sorting (FACS) analysis of cells from spleen, lymph node, bone marrow, and thymus from mice carrying the transgene showed membrane expression of chicken lysozyme on these cells. (J:78307)
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:78307
Hartley SB et al.,
"Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens."
Nature 1991 Oct 24;353(6346):765-9
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All: |
20 reference(s)
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Analysis Tools
