|
|
| Nomenclature |
|
Symbol:
|
Tg(TRAMP)8247Ng
|
|
Name:
|
transgene insertion 8247, Norman M Greenberg
|
|
MGI ID: |
MGI:2384595 |
|
Synonyms: |
PB-Tag, probasin/Tag, TRAMP |
|
Transgene:
|
Tg(TRAMP)8247Ng
Location:
unknown
|
|
Histological analysis of prostate tumors in Tg(TRAMP)8247Ng/0 mice
Show the 1 image(s) involving this allele.
|
 |
|
Transgene
origin |
|
Strain of Origin:
|
C57BL/6
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Expression of the SV40 early region tumor antigen was driven in mouse prostrate epithelium via a rat probasin promoter region fragment (-426/+28 bp). (J:65303, J:73560)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
TRAMP stands for TRansgenic Adenocarcinoma Mouse Prostate. Lines 5666 and 8079 were also produced.
Transgenic mice on a C57BL6 background develop progressive forms of prostate cancer with distant site metastasis. Forms of disease range from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. Tumors are detected in the prostate as early as 10 weeks of age. The tumors have elevated levels of nuclear TRP53 and decreased androgen receptor expression.
|
| References |
|
Original: |
J:65303
Greenberg NM et al.,
"Prostate cancer in a transgenic mouse."
Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3439-43
|
|
All: |
194 reference(s)
|
|
Analysis Tools
