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| Nomenclature |
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Symbol:
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Mc4rtm1Dhu
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Name:
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melanocortin 4 receptor;
targeted mutation 1, Dennis Huszar
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MGI ID: |
MGI:2183586 |
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Synonyms: |
MC4r-, MC-4R(-), MC4r-KO |
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Gene:
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Mc4r
Location:
Chr18:66857715-66860472 bp, - strand
Genetic Position: Chr18,
39.72 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:38224
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Parent Cell Line:
| RF8 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced all but the first 20 nucleotides of the coding region. Northern blot analysis showed a lack of transcript in homozygous mice. (J:38224)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mc4r Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:38224
Huszar D et al.,
"Targeted disruption of the melanocortin-4 receptor results in obesity in mice."
Cell 1997 Jan 10;88(1):131-41
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All: |
48 reference(s)
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Analysis Tools
