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| Nomenclature |
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Symbol:
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Hnf4atm1.1Gonz
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Name:
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hepatic nuclear factor 4, alpha;
targeted mutation 1.1, Frank J Gonzalez
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MGI ID: |
MGI:2183520 |
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Synonyms: |
Hnf4aloxP, HNF4-alphafl, HNF4-alphaflox, HNF4alphaflox, HNF4alpha-flox, hnf4fl |
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Gene:
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Hnf4a
Location:
Chr2:163506808-163572910 bp, + strand
Genetic Position: Chr2,
84.32 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67396
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: This allele was generated by breeding mice carrying Hnf4tm1Gonz with transgenic mice expressing cre recombinase via the EIIa promoter. Expression of cre resulted in the excision of the floxed neomycin cassette, leaving a floxed region containing exons 4 and 5. Hnf4tm1.2Gonz was simultaneously generated by the same strategy. (J:67396)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:67396
Hayhurst GP et al.,
"Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis."
Mol Cell Biol 2001 Feb;21(4):1393-403
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All: |
20 reference(s)
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Analysis Tools
