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| Nomenclature |
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Symbol:
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Gjb2tm1Ugds
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Name:
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gap junction protein, beta 2;
targeted mutation 1, Unite de Genetique des Deficits Sensoriels
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MGI ID: |
MGI:2183509 |
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Synonyms: |
Cx26fl, Cx26fl, Cx26loxP, Gjb2tm1Ptt |
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Gene:
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Gjb2
Location:
Chr14:57098600-57104702 bp, - strand
Genetic Position: Chr14,
30.1 cM, cytoband D1-E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77823
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: The coding region in exon 2 was flanked by a loxP site in intron 1 and a floxed neo cassette inserted into exon 2. Immunohistofluorescence analysis showed that the expression pattern of this floxed allele did not differ from that of wild-type. (J:77823)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:77823
Cohen-Salmon M et al.,
"Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death."
Curr Biol 2002 Jul 9;12(13):1106-11
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All: |
12 reference(s)
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Analysis Tools
