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| Nomenclature |
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Symbol:
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Tg(SCA7)c92QAls
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Name:
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transgene insertion c92Q, Albert R La Spada
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MGI ID: |
MGI:2183508 |
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Synonyms: |
ATXN-92Q, PrP-SCA7-c92Q |
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Transgene:
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Tg(SCA7)c92QAls
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x C3H/HeJ)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The coding region of human SCA7, containing 92 CAG repeats, was inserted into a murine prion protein promoter (MoPrP) construct. Expression was targeted to the outer nuclear layer, the inner nuclear layer, and the ganglion cell layer of the retina. Two lines (6076-92Q and 6561-92Q) were made and this is a representative transgene for the two lines. (J:71971)
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:71971
La Spada AR et al.,
"Polyglutamine-expanded ataxin-7 antagonizes crx function and induces cone-rod dystrophy in a mouse model of sca7. (Erratum: Neuron 2001;32:957)"
Neuron 2001 Sep 27;31(6):913-27
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All: |
7 reference(s)
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Analysis Tools
