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| Nomenclature |
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Symbol:
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Diablotm1Mak
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Name:
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diablo homolog (Drosophila);
targeted mutation 1, Tak Mak
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MGI ID: |
MGI:2183277 |
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Synonyms: |
Smac-, SMAC-KO |
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Gene:
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Diablo
Location:
Chr5:123509765-123524176 bp, - strand
Genetic Position: Chr5,
63.02 cM, cytoband F
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76248
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Parent Cell Line:
| E14K (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exons 2-4 with a PGK-neo cassette via homologous recombination. The null allele was confirmed by Western blot analysis of mouse embryonic fibroblasts (MEFs) derived from E14.5 homozygous mutant embryos. No protein expression was detected. (J:76248)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Diablo Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:76248
Okada H et al.,
"Generation and characterization of Smac/DIABLO-deficient mice."
Mol Cell Biol 2002 May;22(10):3509-17
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All: |
6 reference(s)
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Analysis Tools
