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| Nomenclature |
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Symbol:
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Gfaptm1Pkny
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Name:
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glial fibrillary acidic protein;
targeted mutation 1, Milos Pekny
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MGI ID: |
MGI:2183221 |
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Synonyms: |
GFAP- |
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Gene:
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Gfap
Location:
Chr11:102887336-102900912 bp, - strand
Genetic Position: Chr11,
66.48 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:25093
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The insertion of a neomycin selection cassette deleted 2.0kb of the upstream regulatory region as well as sequence in exon 1 encoding the first 71 amino acids. Northern blot analysis of total brain RNA showed a lack of transcript produced from this allele. Encoded protein was undetected in homozygous mutant mice via immunohistochemical staining of astrocytes. (J:25093, J:96523)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gfap Mutation:
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62 strains or lines available |
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| References |
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Original: |
J:25093
Pekny M et al.,
"Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally."
EMBO J 1995 Apr 18;14(8):1590-8
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All: |
20 reference(s)
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Analysis Tools
