|
|
| Nomenclature |
|
Symbol:
|
Dldtm1Ptl
|
|
Name:
|
dihydrolipoamide dehydrogenase;
targeted mutation 1, Mulchand S Patel
|
|
MGI ID: |
MGI:2182403 |
|
Synonyms: |
Dld-, Dldtm1mjp |
|
Gene:
|
Dld
Location:
Chr12:31331564-31351437 bp, - strand
Genetic Position: Chr12,
13.43 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:45074
|
|
Parent Cell Line:
| E14.1 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Exon 10 was disrupted by the insertion of a neomycin selection cassette. Northern blot analysis of total hepatic and renal RNA showed that transcript levels are reduced by approximately 50% in heterozygous mice. RT-PCR analysis confirmed that the neo transgene was not excised via an altered splicing pattern.
(J:45074)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:45074
Johnson MT et al.,
"Targeted disruption of the murine dihydrolipoamide dehydrogenase gene (Dld) results in perigastrulation lethality."
Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14512-7
|
|
All: |
5 reference(s)
|
|
Analysis Tools
