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| Nomenclature |
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Symbol:
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Mesttm1Masu
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Name:
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mesoderm specific transcript;
targeted mutation 1, M. Azim Surani
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MGI ID: |
MGI:2181803 |
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Synonyms: |
Mest+/-, Mesttm1Lef, Mesttm1Lef-pat |
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Gene:
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Mest
Location:
Chr6:30723547-30744394 bp, + strand
Genetic Position: Chr6,
12.53 cM, cytoband B1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50170
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence encompassing all of exons 3 through 8 and a portion of exon 9 was replaced with a cassette containing an IRES-lacZ-neo fusion gene. RT-PCR analysis of total embryonic RNA showed an absence of normal transcript in animals possessing a targeted paternal allele and a silenced wild-type maternal allele. Paternal transmission of this allele yielded a lacZ expression pattern similar to that of the endogenous gene. (J:50170)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mest Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:50170
Lefebvre L et al.,
"Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest [see comments]"
Nat Genet 1998 Oct;20(2):163-9
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All: |
5 reference(s)
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Analysis Tools
