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| Nomenclature |
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Symbol:
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Foxj1tm1Bph
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Name:
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forkhead box J1;
targeted mutation 1, Brian P Hackett
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MGI ID: |
MGI:2181746 |
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Synonyms: |
hfh-4- |
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Gene:
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Foxj1
Location:
Chr11:116330704-116335399 bp, - strand
Genetic Position: Chr11,
81.16 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50025
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 was replaced with a PGK-neo cassette via homologous recombination. Lack of gene expression in tissues of homozygous mutant animals was confirmed by Northern blot, RT-PCR and in situ hybridization. (J:50025)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Foxj1 Mutation:
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2 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Kartagener Syndrome or Primary Ciliary Dyskinesia (J:50025)
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| References |
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Original: |
J:50025
Chen J et al.,
"Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry."
J Clin Invest 1998 Sep 15;102(6):1077-82
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All: |
3 reference(s)
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Analysis Tools
