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| Nomenclature |
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Symbol:
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Rpe65tm1Tmr
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Name:
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retinal pigment epithelium 65;
targeted mutation 1, T Michael Redmond
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MGI ID: |
MGI:2181399 |
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Synonyms: |
Rpe65- |
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Gene:
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Rpe65
Location:
Chr3:159599233-159624799 bp, + strand
Genetic Position: Chr3,
82.52 cM, cytoband H4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:51293
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1-3 of the gene were replaced with a PGK-neo cassette via homologous recombination. RT-PCR analysis of whole mouse eyes confirmed the null allele in homozygous mutant animals. (J:51293)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rpe65 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:51293
Redmond TM et al.,
"Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle."
Nat Genet 1998 Dec;20(4):344-51
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All: |
62 reference(s)
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Analysis Tools
