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| Nomenclature |
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Symbol:
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Dpcd/Polltm1Nmt
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Name:
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deleted in primary ciliary dyskinesia;
targeted mutation 1, Noboru Motoyama
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MGI ID: |
MGI:2181352 |
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Synonyms: |
Pol lambda- |
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Gene:
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Dpcd
Location:
Chr19:45560615-45578279 bp, + strand
Genetic Position: Chr19,
38.75 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75779
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exons 1-6 with a PGK-neo cassette via homologous recombination. The gene targeting event results in deletion of the translation initiation site, the BRCT motif, and half of the polymerase X domain of Poll. Homozygous mutant animals lack gene expression in testis as determined by Northern blot analysis. Analysis of the genomic region surrounding the Poll gene revealed an uncharacterized gene, named Dpcd, that is predicted to be transcribed from the opposite strand relative to Poll. The deletion of Poll also removes the first exon of Dpcd. (J:75779, J:97294)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:75779
Kobayashi Y et al.,
"Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome."
Mol Cell Biol 2002 Apr;22(8):2769-76
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All: |
2 reference(s)
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Analysis Tools
