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| Nomenclature |
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Symbol:
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Cd44tm1Mak
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Name:
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CD44 antigen;
targeted mutation 1, Tak W Mak
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MGI ID: |
MGI:2181292 |
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Synonyms: |
CD44- |
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Gene:
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Cd44
Location:
Chr2:102811141-102901625 bp, - strand
Genetic Position: Chr2,
54.13 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72658
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The 3' portion of exon 2 and all of exon 3 were replaced by the insertion of a neomycin resistance cassette. The deleted region encodes part of the invariant amino terminus, common to all isoforms. A lack of protein surface expression was observed in spleen, lymph node, and thymus cells via flow cytometry. (J:72658)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cd44 Mutation:
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27 strains or lines available |
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| References |
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Original: |
J:72658
Schmits R et al.,
"CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity."
Blood 1997 Sep 15;90(6):2217-33
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All: |
61 reference(s)
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Analysis Tools
