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| Nomenclature |
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Symbol:
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Socs3tm1Wsa
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Name:
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suppressor of cytokine signaling 3;
targeted mutation 1, Warren S Alexander
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MGI ID: |
MGI:2180861 |
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Synonyms: |
SOCS3- |
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Gene:
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Socs3
Location:
Chr11:117966079-117970047 bp, - strand
Genetic Position: Chr11,
82.96 cM, cytoband E2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70667
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The entire coding region was replaced with a construct containing lacZ and neo. The lacZ was inserted immediately after the start codon, and thus placed under control of the endogenous promoter. Northern blot analysis revealed a lack of transcript in fibroblasts isolated from homozygous mutant embryos stimulated by IFN-gamma. An absence of expression was further confirmed by RT-PCR analysis of total embryonic RNA. The lacZ expression pattern was observed to be the same in whole mount homozygous embryos as it was in heterzygotes. (J:70667)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Socs3 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:70667
Roberts AW et al.,
"Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3."
Proc Natl Acad Sci U S A 2001 Jul 31;98(16):9324-9
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All: |
10 reference(s)
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Analysis Tools
