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| Nomenclature |
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Symbol:
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MaoaTg(H2-K1-Ifnb1)8Seif
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Name:
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monoamine oxidase A;
transgene insertion 8, Isabelle Seif
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MGI ID: |
MGI:2180818 |
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Synonyms: |
MAO-A knockout, MAOA-KO, MaoaTg(H2-IFNB)8Seif, Tg8 |
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Gene:
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Maoa
Location:
ChrX:16619698-16687818 bp, + strand
Genetic Position: ChrX,
11.78 cM, cytoband A2
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Transgene
origin |
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Strain of Origin:
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C3H/HeOuJ
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Random integration of a transgene for IFN beta expressed under the control of a truncated H2-K1 promoter resulted in deletion of a 17 kb region encompassing exons 2 and 3 of the Maoa gene. Enzyme activity was absent in brain and spleen samples from mutant animals. (J:26232)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:26232
Cases O et al.,
"Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA [see comments]"
Science 1995 Jun 23;268(5218):1763-6
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All: |
38 reference(s)
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Analysis Tools
