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| Nomenclature |
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Symbol:
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Cxcr3tm1Wwh
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Name:
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chemokine (C-X-C motif) receptor 3;
targeted mutation 1, Wayne W Hancock
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MGI ID: |
MGI:2180682 |
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Synonyms: |
Cxcr3-, CXCR3-, CXCR3-KO |
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Gene:
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Cxcr3
Location:
ChrX:101731535-101734269 bp, - strand
Genetic Position: ChrX,
44.58 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:65916
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 800 bp of exon 2 was replaced with a PGK-neo cassette via homologous recombination. T cells from homozygous mutant animals lack gene expression and do not exhibit chemotaxis as assessed by RNase protection and chemotaxis assays, respectively. (J:65916)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cxcr3 Mutation:
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3 strains or lines available |
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Notes |
ES cell line = ES-1.
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| References |
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Original: |
J:65916
Hancock WW et al.,
"Requirement of the chemokine receptor CXCR3 for acute allograft rejection"
J Exp Med 2000 Nov 20;192(10):1515-20
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All: |
81 reference(s)
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Analysis Tools
