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| Nomenclature |
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Symbol:
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Ctla4tm1All
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Name:
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cytotoxic T-lymphocyte-associated protein 4;
targeted mutation 1, James P Allison
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MGI ID: |
MGI:2180670 |
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Synonyms: |
CTLA-4-, CTLA-4 KO, Ctla4o, Ctla4o |
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Gene:
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Ctla4
Location:
Chr1:60887000-60915832 bp, + strand
Genetic Position: Chr1,
30.58 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:42481
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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The insertion of neomycin selection cassette under the control of a PGK promoter disrupted exon 3. (J:42481)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:42481
Chambers CA et al.,
"Thymocyte development is normal in CTLA-4-deficient mice."
Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9296-301
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All: |
31 reference(s)
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Analysis Tools
