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| Nomenclature |
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Symbol:
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Adh7tm1Gdu
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Name:
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alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide;
targeted mutation 1, Gregg Duester
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MGI ID: |
MGI:2180102 |
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Synonyms: |
Adh4- |
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Gene:
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Adh7
Location:
Chr3:138217773-138232042 bp, + strand
Genetic Position: Chr3,
64.13 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:56168
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neo cassette replaced the promoter and exons 1 through 6. Northern blot analysis showed an absence of transcript in extracts isolated from the stomach and skin tissue of homozygous mutant mice. Western blot analysis confirmed a lack of encoded protein and normal levels of other alcohol dehydrogenases in homozygous mutant animals. (J:56168)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Adh7 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:56168
Deltour L et al.,
"Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice."
Dev Genet 1999;25(1):1-10
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All: |
7 reference(s)
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Analysis Tools
