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| Nomenclature |
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Symbol:
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Abcb1atm1Bor
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Name:
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ATP-binding cassette, sub-family B (MDR/TAP), member 1A;
targeted mutation 1, Piet Borst
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MGI ID: |
MGI:2180054 |
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Synonyms: |
mdr1a- |
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Gene:
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Abcb1a
Location:
Chr5:8660077-8748575 bp, + strand
Genetic Position: Chr5,
3.43 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:18554
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1.6-kb fragment containing exons 6 and 7 and encoding the extracellular, transmembrane, and cytoplasmic domains, was replaced by the insertion of a hygromycin cassette. While low levels of transcript were detected in the intestines of homozygous mutant mice by RNAase protection assays, immunoblot analysis showed an absence of protein expression. (J:18554)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abcb1a Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:18554
Schinkel AH et al.,
"Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs."
Cell 1994 May 20;77(4):491-502
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All: |
78 reference(s)
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Analysis Tools
