|
|
| Nomenclature |
|
Symbol:
|
Tff1tm1Mrio
|
|
Name:
|
trefoil factor 1;
targeted mutation 1, Marie-Christine Rio
|
|
MGI ID: |
MGI:2179220 |
|
Synonyms: |
mpS2-, TFF1- |
|
Gene:
|
Tff1
Location:
Chr17:31161396-31165053 bp, - strand
Genetic Position: Chr17,
15.8 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:35923
|
|
Parent Cell Line:
| D3 (ES Cell) |
|
Strain of Origin:
|
129S2/SvPas
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Exon 2 of this gene was disrupted by the insertion of a neo cassette via homologous recombination. Northern blot analysis detected mutant transcript from the stomachs of homozygous mutant animals. Western blot of gastric cytosol and immunohistochemistry of stomach from homozygous mutant animals did not detect protein product. (J:35923)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Tff1 Mutation:
|
3 strains or lines available |
|
| References |
|
Original: |
J:35923
Lefebvre O et al.,
"Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein [see comments]"
Science 1996 Oct 11;274(5285):259-62
|
|
All: |
9 reference(s)
|
|
Analysis Tools
