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| Nomenclature |
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Symbol:
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Casp3tm1Mak
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Name:
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caspase 3;
targeted mutation 1, Tak W Mak
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MGI ID: |
MGI:2178778 |
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Synonyms: |
Casp3-, CPP32ex3- |
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Gene:
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Casp3
Location:
Chr8:46617449-46638706 bp, + strand
Genetic Position: Chr8,
26.39 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:74972
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Parent Cell Line:
| E14K (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment containing exon 3 was replaced with a neomycin selection cassette. Western blot analysis on lysates derived from doubly targeted ES cells confirmed that no detectable protein was produced from this allele. (J:74972)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Casp3 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:74972
Woo M et al.,
"Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes."
Genes Dev 1998 Mar 15;12(6):806-19
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All: |
16 reference(s)
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Analysis Tools
