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| Nomenclature |
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Symbol:
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Capn3tm1Jsb
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Name:
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calpain 3;
targeted mutation 1, Jacques S Beckmann
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MGI ID: |
MGI:2177929 |
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Synonyms: |
CAPN3- |
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Gene:
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Capn3
Location:
Chr2:120456019-120504913 bp, + strand
Genetic Position: Chr2,
60.31 cM
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Dystrophic muscle in Capn3tm1Jsb/Capn3tm1Jsb mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66862
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment containing exons 2 and 3 was replaced by a neomycin selection cassette. Western blot analysis on muscle extracts derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:66862)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Capn3 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:66862
Richard I et al.,
"Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice."
J Cell Biol 2000 Dec 25;151(7):1583-90
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All: |
6 reference(s)
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Analysis Tools
