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| Nomenclature |
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Symbol:
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Eif2ak3tm1Dron
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Name:
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eukaryotic translation initiation factor 2 alpha kinase 3;
targeted mutation 1, David Ron
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MGI ID: |
MGI:2177666 |
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Synonyms: |
perk - |
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Gene:
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Eif2ak3
Location:
Chr6:70844515-70905245 bp, + strand
Genetic Position: Chr6,
32.09 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70005
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Parent Cell Line:
| W4 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced 1.6 kb of DNA containing the transmembrane domain. Northern blot analysis demonstrated that at least 10-fold less transcript was produced from this allele that the wild-type. However, western blot analysis on cells derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:62257)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:62257
Harding HP et al.,
"Perk is essential for translational regulation and cell survival during the unfolded protein response."
Mol Cell 2000 May;5(5):897-904
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All: |
17 reference(s)
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Analysis Tools
