|
|
| Nomenclature |
|
Symbol:
|
Admtm1Unc
|
|
Name:
|
adrenomedullin;
targeted mutation 1, University of North Carolina
|
|
MGI ID: |
MGI:2176598 |
|
Synonyms: |
AM- |
|
Gene:
|
Adm
Location:
Chr7:110627669-110629819 bp, + strand
Genetic Position: Chr7,
57.7 cM
|
|
Massive generalized edema of Admtm1Unc/Admtm1Unc embryos
Show the 5 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:67044
|
|
Parent Cell Line:
| TC1/TC-1 (ES Cell) |
|
Strain of Origin:
|
129S6/SvEvTac
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Reporter) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: An in-frame EGFP gene and a neomycin resistance cassette were inserted into exon 2, and a genomic fragment corresponding to exons 3 and 4 was deleted. RT-PCR analysis on embryonic RNA of homozygotes demonstrated that no detectable Adm transcript was expressed from this allele. (J:67044)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Adm Mutation:
|
1 strain or line available |
|
| References |
|
Original: |
J:67044
Caron KM et al.,
"Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene."
Proc Natl Acad Sci U S A 2001 Jan 16;98(2):615-9
|
|
All: |
6 reference(s)
|
|
Analysis Tools
