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| Nomenclature |
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Symbol:
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Ptpn11tm1Rbn
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Name:
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protein tyrosine phosphatase, non-receptor type 11;
targeted mutation 1, Daniel U Rabin
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MGI ID: |
MGI:2176526 |
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Synonyms: |
syp |
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Gene:
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Ptpn11
Location:
Chr5:121130533-121191397 bp, - strand
Genetic Position: Chr5,
61.72 cM, cytoband F
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:35137
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 2 and flanking sequences. Western blot analysis on lyastes prepared from various tissues of heterozygous mice confirmed that protein levels were reduced by 40-50% in all tissue examined. (J:35137)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ptpn11 Mutation:
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20 strains or lines available |
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Notes |
The ES cell line used was G1 (Bayer Corp., unpublished). This appears to have been derived from an unspecified subline of 129.
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| References |
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Original: |
J:35137
Arrandale JM et al.,
"Insulin signaling in mice expressing reduced levels of Syp."
J Biol Chem 1996 Aug 30;271(35):21353-8
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All: |
2 reference(s)
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Analysis Tools
