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| Nomenclature |
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Symbol:
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Nf1tm1Par
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Name:
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neurofibromatosis 1;
targeted mutation 1, Luis F Parada
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MGI ID: |
MGI:2176057 |
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Synonyms: |
Nf1flox, Nf1flox |
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Gene:
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Nf1
Location:
Chr11:79339693-79581612 bp, + strand
Genetic Position: Chr11,
46.74 cM, cytoband B4-5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:68558
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP-neomycin selection cassette was inserted into intron 30 and a single loxP site was inserted into intron 32. (J:68558)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Astrocytoma (J:134611)
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| References |
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Original: |
J:68558
Zhu Y et al.,
"Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain."
Genes Dev 2001 Apr 1;15(7):859-76
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All: |
70 reference(s)
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Analysis Tools
