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| Nomenclature |
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Symbol:
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Ccl2tm1Rol
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Name:
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chemokine (C-C motif) ligand 2;
targeted mutation 1, Barrett J Rollins
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MGI ID: |
MGI:2175911 |
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Synonyms: |
CCL2-, CCL2KO, (MCP)1-, MCP-1-, MCP-1KO, Scya2- |
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Gene:
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Ccl2
Location:
Chr11:82035571-82037453 bp, + strand
Genetic Position: Chr11,
49.82 cM, cytoband C-E1
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Ccl2tm1Rol/Ccl2tm1Rol mice with experimental autoimmune encephalomyelitis show fewer inflammatory infiltrates in the spinal cord
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45920
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A small deletion and an in frame stop codon were created in exon 1. A PGK-neomycin resistance cassette was also inserted into exon 2. Secreted protein was not detected in stimulated peritoneal macrophages from homozygous mutant mice. (J:45920)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Age-related macular degeneration (J:126935, J:147328)
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| References |
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Original: |
J:45920
Lu B et al.,
"Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice."
J Exp Med 1998 Feb 16;187(4):601-8
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All: |
152 reference(s)
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Analysis Tools
