|
|
| Nomenclature |
|
Symbol:
|
Blmtm3Brd
|
|
Name:
|
Bloom syndrome, RecQ helicase-like;
targeted mutation 3, Allan Bradley
|
|
MGI ID: |
MGI:2158670 |
|
Synonyms: |
Blm-, Blmm3 |
|
Gene:
|
Blm
Location:
Chr7:80454993-80535119 bp, - strand
Genetic Position: Chr7,
45.65 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:66261
|
|
Parent Cell Line:
| AB2.2 (ES Cell) |
|
Strain of Origin:
|
129S7/SvEvBrd-Hprtb-m2
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: This allele is a derivative of Blmtm2Brd. Three copies of a targeting vector that contained loxP sites inserted into the gene. Cre mediated recombination led to a deletion of the copies. This allele retains an extra copy of exon 3. However, western blot analysis on protein extracts of testes demonstrated that no detectable protein was produced from this allele. (J:66261)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:66261
Luo G et al.,
"Cancer predisposition caused by elevated mitotic recombination in bloom mice"
Nat Genet 2000 Dec;26(4):424-9
|
|
All: |
12 reference(s)
|
|
Analysis Tools
