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| Nomenclature |
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Symbol:
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Prf1tm1Clrk
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Name:
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perforin 1 (pore forming protein);
targeted mutation 1, William R Clark
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MGI ID: |
MGI:2158403 |
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Synonyms: |
perforin-less (-), PKO |
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Gene:
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Prf1
Location:
Chr10:61297836-61304263 bp, + strand
Genetic Position: Chr10,
32.18 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:21531
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance gene was inserted into exon 2. Western blot analysis on splenocytes derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:21531)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Prf1 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:21531
Walsh CM et al.,
"Immune function in mice lacking the perforin gene."
Proc Natl Acad Sci U S A 1994 Nov 8;91(23):10854-8
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All: |
56 reference(s)
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Analysis Tools
