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| Nomenclature |
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Symbol:
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Nr4a2tm1Tpe
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Name:
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nuclear receptor subfamily 4, group A, member 2;
targeted mutation 1, Thomas Perlmann
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MGI ID: |
MGI:2157566 |
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Synonyms: |
Nurr1- |
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Gene:
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Nr4a2
Location:
Chr2:57106830-57124003 bp, - strand
Genetic Position: Chr2,
31.66 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39661
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Insertion of a neomycin resistance cassette replaces the sequence encoding the N terminal transactivation and DNA binding domains (exons 2,3 and part of 4). In situ hybridization detected no transcript from this gene in homozygous mutant mice. (J:39661)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nr4a2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:39661
Zetterstrom RH et al.,
"Dopamine neuron agenesis in Nurr1-deficient mice [see comments]"
Science 1997 Apr 11;276(5310):248-50
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All: |
14 reference(s)
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Analysis Tools
