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| Nomenclature |
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Symbol:
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Apobec1tm1Ddsn
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Name:
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apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1;
targeted mutation 1, Nicholas O Davidson
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MGI ID: |
MGI:2157186 |
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Synonyms: |
apoB100-, apobec-1-, apobec-1 KO |
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Gene:
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Apobec1
Location:
Chr6:122577792-122602444 bp, - strand
Genetic Position: Chr6,
57.68 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:32731
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Parent Cell Line:
| RF8 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment containing exon 6, encoding the zinc finger and catalytic glutamate, was replaced with a neomycin selection cassette. No transcript was detectable in RNAse protection assays on RNA isolated from liver and small intestine of homozygous mice. (J:32731)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Apobec1 Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:32731
Hirano K et al.,
"Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48."
J Biol Chem 1996 Apr 26;271(17):9887-90
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All: |
24 reference(s)
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Analysis Tools
