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| Nomenclature |
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Symbol:
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Adora2atm1Jfc
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Name:
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adenosine A2a receptor;
targeted mutation 1, Jiang-Fan Chen
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MGI ID: |
MGI:2155985 |
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Synonyms: |
A2A, A2AAR-, A2A KO, A2aR-, A2AR KO, Adora2atm1Chren, gKO |
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Gene:
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Adora2a
Location:
Chr10:75316943-75334788 bp, + strand
Genetic Position: Chr10,
38.52 cM, cytoband B5.3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:73594
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Part of exon 2 and intron 2 was replaced by a neomycin selection cassette. The absence of functional protein was demonstrated in homozygous mice by in situ binding assays and neurochemical tests. (J:73594)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:73594
Chen JF et al.,
"A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice."
J Neurosci 1999 Nov 1;19(21):9192-200
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All: |
73 reference(s)
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Analysis Tools
