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| Nomenclature |
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Symbol:
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Fmodtm1Aol
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Name:
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fibromodulin;
targeted mutation 1, Ake Oldberg
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MGI ID: |
MGI:2154550 |
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Synonyms: |
Fmod- |
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Gene:
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Fmod
Location:
Chr1:134037254-134048277 bp, + strand
Genetic Position: Chr1,
58.09 cM
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Abnormal tendon collagen fiber bundles in Fmodtm1Aol/Fmod+ and Fmodtm1Aol/Fmodtm1Aol tails
Show the 5 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:54069
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 2, at a position corresponding to amino acid 8 (tryptophan) in the mature protein. (J:54069)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fmod Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:54069
Svensson L et al.,
"Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon."
J Biol Chem 1999 Apr 2;274(14):9636-47
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All: |
13 reference(s)
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Analysis Tools
