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| Nomenclature |
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Symbol:
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Bgntm1Mfy
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Name:
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biglycan;
targeted mutation 1, Marian F Young
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MGI ID: |
MGI:2153057 |
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Synonyms: |
Bgn-/0, bgn-KO |
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Gene:
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Bgn
Location:
ChrX:73483602-73495933 bp, + strand
Genetic Position: ChrX,
37.33 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:49647
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that no transcript was detectable in hemizyogous male mice and western blot analysis showed that the protein was not expressed in hemizygous male mice. (J:49647)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Preterm premature rupture of fetal membranes (PPROM; J:180914) in mice homozygous for Bgntm1Mfy and Dcntm1Ioz
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| References |
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Original: |
J:49647
Xu T et al.,
"Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice."
Nat Genet 1998 Sep;20(1):78-82
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All: |
37 reference(s)
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Analysis Tools
