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| Nomenclature |
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Symbol:
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Dcntm1Ioz
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Name:
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decorin;
targeted mutation 1, Renato V Iozzo
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MGI ID: |
MGI:2153002 |
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Synonyms: |
Dcn- |
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Gene:
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Dcn
Location:
Chr10:97479500-97518162 bp, + strand
Genetic Position: Chr10,
50.27 cM
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Dcntm1Ioz/Dcntm1Ioz mice display thin and fragile skin
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39212
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that no transcript was detectable in sternum, heart, liver or kidney of homozygous mice. Immunoblot analysis on extracts of tail tissue revealed that no expressed protein was detectable in homozygous mice. (J:39212)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Dcn Mutation:
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1 strain or line available |
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Notes |
Phenotypic Similarity to Human Syndrome: Ehlers-Danlos syndrome (J:39212, J:91512)
Phenotypic Similarity to Human Syndrome: Preterm premature rupture of fetal membranes (PPROM; J:180914) in mice homozygous for Bgntm1Mfy and Dcntm1Ioz
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| References |
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Original: |
J:39212
Danielson KG et al.,
"Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility."
J Cell Biol 1997 Feb 10;136(3):729-43
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All: |
28 reference(s)
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Analysis Tools
