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| Nomenclature |
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Symbol:
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Oattm1Dva
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Name:
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ornithine aminotransferase;
targeted mutation 1, David Valle
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MGI ID: |
MGI:2150441 |
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Gene:
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Oat
Location:
Chr7:132557475-132576398 bp, - strand
Genetic Position: Chr7,
76.3 cM
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Retinal histopathology of Oattm1Dva/Oattm1Dva mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29269
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette was inserted into exon 3 (codon 40 of the 439 codon reading frame) of the gene. This insertion truncated the peptide 13 amino acid residues downstream of the cleavage site for the N-terminal mitochondrial targeting sequence. Southern blots showed production of a truncated protein in mutant mice, and functional assasys showed lack of enzymatic activity of the truncated protein. (J:29269)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Oat Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:29269
Wang T et al.,
"Mice lacking ornithine-delta-aminotransferase have paradoxical neonatal hypoornithinaemia and retinal degeneration."
Nat Genet 1995 Oct;11(2):185-90
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All: |
3 reference(s)
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Analysis Tools
