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| Nomenclature |
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Symbol:
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Thrbtm1.1Syc
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Name:
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thyroid hormone receptor beta;
targeted mutation 1.1, Sheue-yann Cheng
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MGI ID: |
MGI:2137592 |
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Synonyms: |
TRbetaPV, TRbetaPV, TRbeta PV |
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Gene:
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Thrb
Location:
Chr14:17660960-18038086 bp, + strand
Genetic Position: Chr14,
7.08 cM, cytoband A3
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Histology of thyroid glands of wild-type, Thrbtm1.1Syc/Thrb+ and Thrbtm1.1Syc/Thrbtm1.1Syc mice.
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:65885
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Mice homozygous for the Thrbtm1Syc allele were mated to EIIa-Cre transgenic mice to generate mice that carry a germline deletion of the neomycin resistance gene. RT-PCR studies of liver and brown adipocytes from mice homozygous for the final allele indicate that the mutant allele is expressed at the RNA level in expected T3 target tissues. Northern analyses of liver, heart, and brain indicate that levels of transcription of both the mutated and wild-type alleles were not significantly different in heterozygous and homozygous mutant mice, and wild-type mice. (J:65885)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Thrb Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:65885
Kaneshige M et al.,
"Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone"
Proc Natl Acad Sci U S A 2000 Nov 21;97(24):13209-14
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All: |
44 reference(s)
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Analysis Tools
