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| Nomenclature |
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Symbol:
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Gabra1tm1.1Geh
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Name:
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gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1;
targeted mutation 1.1, Gregg E Homanics
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MGI ID: |
MGI:2137421 |
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Synonyms: |
alpha1-, alpha10 |
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Gene:
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Gabra1
Location:
Chr11:42130939-42182930 bp, - strand
Genetic Position: Chr11,
24.97 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70505
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele is a derivative of Gabra1tm1Geh in which the loxP flanked sequences were deleted in the germline by crossing mice carrying this allele to mice carrying a ubiquitously expressed Cre recombinase. (J:70505)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gabra1 Mutation:
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4 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Essential Tremors (J:174980)
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| References |
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Original: |
J:70505
Vicini S et al.,
"GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons."
J Neurosci 2001 May 1;21(9):3009-16
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All: |
18 reference(s)
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Analysis Tools
