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| Nomenclature |
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Symbol:
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Aplp2tm1Dbo
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Name:
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amyloid beta (A4) precursor-like protein 2;
targeted mutation 1, David R Borchelt
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MGI ID: |
MGI:2137246 |
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Synonyms: |
APLP2- |
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Gene:
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Aplp2
Location:
Chr9:31149557-31211815 bp, - strand
Genetic Position: Chr9,
16.66 cM, cytoband A2-B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45851
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Replacement of the promoter region and first exon with a neomycin cassette. Western blot analysis on samples derived from nervous tissue and other peripheral tissues of homozygous mutant mice failed to detect any protein. (J:45851)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:45851
von Koch CS et al.,
"Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice."
Neurobiol Aging 1997 Nov-Dec;18(6):661-9
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All: |
27 reference(s)
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Analysis Tools
