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| Nomenclature |
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Symbol:
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Gdnftm1Rosl
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Name:
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glial cell line derived neurotrophic factor;
targeted mutation 1, Arnon Rosenthal
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MGI ID: |
MGI:2136843 |
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Synonyms: |
Gdnf-, GdnflacZ, GDNF-LZ |
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Gene:
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Gdnf
Location:
Chr15:7811011-7837575 bp, + strand
Genetic Position: Chr15,
3.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:33808
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A lacZ gene followed by a neomycin cassette was inserted in frame after the codon corresponding to amino acid 102. This allele expresses a fusion protein consisting of the first 102 amino acids of GDNF fused to beta-galactosidase. (J:33808)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gdnf Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:33808
Moore MW et al.,
"Renal and neuronal abnormalities in mice lacking GDNF."
Nature 1996 Jul 4;382(6586):76-9
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All: |
18 reference(s)
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Analysis Tools
