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| Nomenclature |
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Symbol:
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Hspg2tm1Ref
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Name:
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perlecan (heparan sulfate proteoglycan 2);
targeted mutation 1, Reinhard Fassler
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MGI ID: |
MGI:1934892 |
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Gene:
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Hspg2
Location:
Chr4:137468769-137570630 bp, + strand
Genetic Position: Chr4,
69.93 cM
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Hemopericardium development in E10.5 Hspg2tm1Ref/Hspg2tm1Ref embryos
Show the 6 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58700
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: A neomycin/thymidine kinase cassette flanked by single loxP sites was inserted into intron 5 and a single loxP site was inserted into intron 6 of the gene. Correctly targeted ES cells were treated with cre recombinase and, in resultant clones, the sequence between the outermost loxP sites (including the neomycin/thymidine kinase cassette, part of intron 5, exon 6, and part of intron 6) was deleted. (J:58700)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:58700
Costell M et al.,
"Perlecan maintains the integrity of cartilage and some basement membranes."
J Cell Biol 1999 Nov 29;147(5):1109-22
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All: |
7 reference(s)
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Analysis Tools
